RESEARCH
HIGHER DEGREE
Doctor of Philosophy
The Effects of SMA-Pirarubicin as a Selective Tumour Targeting Agent for the Treatment of Colorectal Cancer Liver metastases, PhD, University of Melbourne, 2011
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Honours
Effect of Thalidomide on Colorectal Cancer Liver Metastases, BBiomed Sci Honours, University of Melbourne 2004
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Research Associate - VERITAS - Victorian Collaborative for Education, Research, Innovation, Training and Audit by Surgical Trainees
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INTERNATIONAL MULTICENTRE COLLABORATIVES
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SPACEFLOT, An International Multicentre Cohort Study, Hospital Lead https://www.space-flot.com/
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COVIDSurg GlobalSurg Collaborative, Birmingham, UK, Hospital Lead https://globalsurg.org/covidsurg/
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POSTVentT, University of Western Australia, Perth, State Lead-TAS https://research-au.net/postventt/
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PUBLICATIONS
First Author
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1. Daruwalla J, Sachithanandan N, Andrews D & Miller, J. Ectopic intravagal parathyroid adenoma. Head and Neck, 37(12):200-
204, 2015.
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2. Daruwalla J, Malcontenti Wilson, Muralidharan V & Christophi C. Styrene maleic acid copolymer–pirarubicin induces tumor-
selective oxidative stress and decreases tumor hypoxia as possible treatment of colorectal cancer liver metastases. Surgery,
158(1):236-247, 2015.
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3. Daruwalla J, Murray D, Pande G, An unusual case of small bowel obstrcution. ANZJS, 85(5):391-392, 2015
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4. Daruwalla J, Hadge A, Wen S & Nikfarjam M. High fat diet is not associated with stimulation of colorectal cancer liver
metastases. World Journal of Surgical Research. 3:38, 2014.
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5. Daruwalla J, Maddern G. The effect of fatigue on simulated laparoscopic surgical skills: a comparative historical control
cohort study. ANZ Journal of Surgery. 84:137–142, 2014.
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6. Daruwalla J, Malcontenti Wilson, Muralidharan V, Maeda H & Christophi C. In vitro and in vivo evaluation of tumor targeting
SMA- pirarubicin micelles: Survival improvement and inhibition of liver metastases. Cancer Science. 101(8):1866-1874,
2010. Figure 7 used - Front Cover of issue (see background).
7. Daruwalla J, Greish K, Malcontenti-Wilson C, Muralidharan V, Iyer A, Maeda H, Christophi C. Styrene maleic acid-pirarubicin
disrupts tumor microcirculation and enhances the permeability of colorectal liver metastases. Journal of Vascular Research. 46 (3): 218-228, 2009.
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8. Daruwalla J, Greish K, Malcontenti-Wilson C, Muralidharan V, Maeda H & Christophi C. SMA-pirarubicin induces tumor selective oxidative damage and reduces tumor hypoxia. Annals of Oncology. 18 (VII34-VII34), 2007.
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9. Daruwalla J, Nikfarjam M, Greish K, Malcontenti Wilson, Maeda H & Christophi C. Evaluation of the effect of SMA-pirarubicin
micelles on colorectal cancer liver metastases and of hyperbaric oxygen in CBA mice. Journal of Drug Targeting. 15(7-8):
487- 495, 2007.
10. Daruwalla J, Malcontenti Wilson, Maeda H & Christophi C. Hyperbaric oxygen therapy for malignancy: A review. World
Journal of Surgery. 30(12): 2112-2131, 2006.
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11. Daruwalla J and Christophi C. The effect of hyperbaric oxygen therapy on tumour growth in a mouse model of colorectal
cancer liver metastases. European Journal of Cancer. 42(18): 3304-3311, 2006
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12. Daruwalla J, Greish K, Nikfarjam M, Malcontenti-Wilson C, Maeda H & Christophi C. SMA-pirarubicin inhibits growth of colorectal cancer liver metastases in an animal model. Cancer Research. 66 (8): 721, 2006.
13. Daruwalla J, Nikfarham M, Malcontenti Wilson, Fanartzis M & Christophi C. Effect of thalidomide on colorectal liver
metastases. Journal of Surgical Oncology. 91(2): 134-140, 2005.
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Co-Authored
1. Determination of “borderline resectable” pancreatic cancer – a global assessment of 30 shades of grey. HPB, Manuscript Number: HPB-D-23-00043R1 (Submitted June 2023)
2. COVIDSurg3 Collaborative. Reducing the environmental impact of surgery on a global scale: systematic review and co- prioritization with healthcare workers in 132 countries. British Journal of Surgery, Volume 110, Issue 7, Pages 804–817, July 2023. ​
3. POSTVenTT Collaborative. The management of peri-operative anaemia in patients undergoing major abdominal surgery in Australia and New Zealand: a prospective cohort study. Medical Journal of Australia, 217(9):487-493. doi: 10.5694/mja2.51725, Novemeber 2022.
4. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries. Lancet, 5;400(10363):1607-1617. doi: 10.1016/S0140-6736(22)01846-3. November 2022.
5. COVIDSurg Collaborative*. SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. Anaesthesia, doi: 10.1111/anae.15563, August 2021.
6. COVIDSurg Collaborative*. Resilience of elective cancer surgery systems during COVID-19 lockdowns: International, prospective cohort study of planned surgery for 15 tumour types in 61 countries Annals of Oncology, 33 (5), August 2021.
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7. COVIDSurg Collaborative and GlobalSurg Collaborative. SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. British Journal of Surgery, March 2021.
Authorship: https://biblio.ugent.be/publication/8699263/file/8699266.docx
8. COVIDSurg Collaborative and GlobalSurg Collaborative. Timing of surgery following SARS-CoV-2 infection an international prospective cohort study. Anaesthesia, March 2021.
Authorship: https://biblio.ugent.be/publication/8699263/file/8699266.docx
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9. Gao N, Guest G, Thomson BN, Bozin M, Mann B, Tan S, Clark DA, Daruwalla J, et al., Laparoscopic or open appendicectomy
for suspected appendicitis in pregnancy, evaluation of fetal outcome in Australia. ANZJS. Sept 6 Epub 2016
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10. Fifis T, Nguyen L, Malcontenti Wilson, Chan L, Costa P, Daruwalla J, Nikfarjam M, Muralidharan V, Waltham M, Thompson E & Christophi C. Treatment with the vascular disruptive agent OXi4503 induces an immediate and widespread Epithelial to
Mesenchymal Transition (EMT) in the surviving tumor, Cancer Medicine. 2(5): 595-610 2013
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11. Satasivam P, Lim M, Reeves F, Daruwalla J, Casan J, Lim C & Royce P. The effect of oral anticoagulation on the incidence and
management of haematuria in a contemporary Australian patient cohort. British Journal of Urology International.
110(Suppl 4): 80-84, 2012
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12. Maeda H, Bharate G, & Daruwalla J. Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect.
European Journal of Pharmacy and Biopharmacy. 71(3): 409-419, 2009
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13. Chan LS, Daruwalla J & Christophi C. Selective targeting of the tumour vasculature. ANZ Journal of Surgery. 78(11): 955-967,
2008
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14. Fifis T, Lam I, Malcontenti-Wilson C, Daruwalla J, Chan L, Harun N, Christophi C & Loveland B. Immunization with Heat- Stressed Tumour Cells Reduces Colorectal Cancer Liver Metastases. Tissue Antigens. 66 (5): 416-417, 2005.
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15. Nikfarjam M, Malcontenti-Wilson C, Fanartzis M, Daruwalla J, & Christophi C. A model of partial hepatectomy in mice.
Journal of Investigative Surgery. 17(5): 291-294, 2004.